Ortiz was lifted from the game for a pinch runner shortly thereafter, and was met by most of his AL teammates on the field.
Johnny Cueto helped the Kansas City Royals win the World Series a year ago, but his former teammates Eric Hosmer and Salvador Perez didn't exactly shake hands with him or give him friendly hugs.
Fans, even some from outside of Kansas City, were thrilled for Hosmer.
In the bottom of the 2nd inning, Hosmer hit a solo home run off former Royal Johnny Cueto.
Is that any way to treat a guy who helped you win a World Series?
On the topic of drug testing, Manfred and MLB Players Association president Tony Clark gushed about the system in place, although some players have claimed they were unaware how a banned substance got into their system.
A historically youthful batch of all-stars showed promise.
"I would have loved to be able to get them out, but I just left two pitches up and that was the story", Cueto said after failing to complete two innings of work. The Padres honored beloved closer Trevor Hoffman, and he ran in from the bullpen to the staple of AC/DC's Hell's Bells to deliver the game ball.
The Giants were represented by Buster Posey and Brandon Belt as their position players in the 87th MLB All-Star Game.
The Game 1 Series host has won six of the last seven titles and 24 of the last 30. He grounded out, then came to bat against Marlins ace Jose Fernandez, 17 years his junior, in his second and final all-star at-bat.
"I was supposed to hit a home run my second at bat", Ortiz laughed later.
Sale had retired the first two batters on just three pitches. Ortiz received a long standing ovation from the crowd in San Diego as he left.
Kris Bryant of the Chicago Cubs homered to open the scoring. Baseball's youth movement, all-star intrigue, and local sentimentality coalesced in the 24-year-old Bryant.
San Diego is a hotbed of baseball talent.
Cabrera entered the game in the top of the seventh inning at first base for Hosmer, who went 2-for-3 with two RBI.
Buehrle also pitched seven innings on the Saturday before he started the Tuesday All-Star Game in 2005 in Detroit.
This was Hamels' fourth All-Star Game. Cueto (L) put another man on in front of Royals' catcher Salvador Perez, who blasted a two run homer (1) to left to make it 3-1. Bryant ambushed a first-pitch, 96 miles per hour fastball, crushing it off the facing of the upper deck in left field for a homer.
"Hopefully this is something we can all rally upon for the second half and find a way to use that home-field advantage", Hosmer said. "I said, 'No, I'm going to take it'".
Next time through the order, Hosmer would single in the fourth and final AL run.
The 2016 MLB All-Star Game in San Diego was everything you'd expect when some of the best players in the world gather to play one another. He has now allowed two runs on four hits with five strikeouts in five All-Star innings. Scherzer worked a scoreless inning.