Djokovic claimed a first French Open title last month, having triumphed for a sixth time in Australia at the start of the year, and was favourite to become the first man since Rod Laver in 1969 to win the first three Grand Slams of the year. "I managed to win four Grand Slams in a row two different seasons. I want to try to focus on that", the No. 1-seeded Djokovic said, "rather than failure".
In-form American Steve Johnson reached the fourth round of a major for the first time by defeating former semi-finalist Grigor Dimitrov of Bulgaria 6-7 (6/8), 7-6 (7/3), 6-4, 6-2.
However, Sam Querrey had other plans for Djokovic.
Djokovic had admitted that he hadn't been "100 percent healthy" in the match with Querrey and was spotted rubbing his left shoulder as the tie slipped away.
In the midst of his historic win against world No. 1 Novak Djokovic on Friday night and Saturday afternoon, Sam Querrey was playing miniature golf in the locker room. Way back in there somewhere you are thinking one thing; that it doesn't matter, but you are thinking it does matter.
After initial nerves on Saturday, Querrey showed great composure, saving 11 out of 12 break points in the fourth set, several with aces, as Djokovic tried everything to take the match into a deciding set.
The drenched tournament cleared a backlog of matches and finally closed the second round yesterday, when two-time champion Petra Kvitova lost to Ekaterina Makarova 7-5 7-6 (7-5).
That game included two calls against Djokovic which, according to the BBC broadcast, were incorrect - but he was out of challenges and so couldn't ask for a review.
Murray beat Millman 6-3 7-5 6-2, after the world number 67 put up some stern resistance on Centre Court. The rain delays were the same for both of us. "In the tiebreak, I was leading". But, in the end he could not take it. Eliminated. "I just need some rest".
How surprising was this result?
Laver's record safe as Djokovic feels weight of history
Djokovic had hoped to win his third straight Wimbledon title and secure the third leg of a calendar Slam.
Djokovic has faced Nadal twice this year and has won all of their last seven meetings, most recently in the semifinal round of Indian Wells. "If I didn't win, there would have been a lot of, 'Wow, it was kind of a fluky match against Novak because you didn't back it up'".
"He served very well, as he usually does", Djokovic said, "and I think that part of his game was brutal today".
Querrey reached a career-best ranking of No. 17 in 2011, but he's never quite lived up to the potential his big serve and forehand appeared to promise when he was younger.
So really, why not a little more Sam Querrey? I don't know what his situation was health-wise, but it didn't look like he was ready to play a big match.
Nothing resonated, of course, like Djokovic's defeat.
Laver also won the Grand Slam in 1962 and was only the second man to achieve the feat after American Don Budge in 1938.
- Djokovic was on a 30-match winning streak at the Grand Slams, an Open era record for consecutive wins.
"It must be natural", Querrey said, "because I didn't really know I did it".