Kerber beat five-time Wimbledon champ Venus Williams 6-4, 6-4 on Thursday to advance to her second major final, and the 2016 Wimbledon title match will be the first time that two players will meet in two different major finals in the same year since Amelie Mauresmo beat Justine Henin in the Australian Open and Wimbledon finals in 2006.
And big sister, Venus, is not totally out of Wimbledon as she teamed up with Serena to book a semi-final place in the doubles event when they beat Elena Vesnina and Ekaterina Makarova 7-6, 4-6, 6-2.
The American will now take on Angelique Kerber after she denied Venus Williams the chance to play in a ninth Grand Slam final against her sister.
Vesnina, a three-times grand slam doubles victor, had battled through to a first major singles semi but her challenge crumbled quickly as dropped her opening two service games.
In her third service game of the set Vesnina faced two break points and with the help of one mistake from Williams was able to save one, but the American then hit a forehand victor to claim the third break in a row and serve for a place in the final.
"I knew she was playing very well at the moment so I was ready, trying to move well and go for it and everything worked".
"It's never easy out there", the No. 1-seeded Williams said in an interview with the BBC after leaving Centre Court.
Serena, 34, fired 11 aces, 28 winners and committed just seven unforced errors, breaking serve five times to reach her 28th Grand Slam final.
"Obviously, I'm 0 for 2, so determined to get at least one this year", Williams said. The fourth-ranked German will be playing in her first Wimbledon final.
Champion: Williams is aiming for her seventh Wimbledon title this weekend.
"She was always an idol for me, I have watched a lot of matches, on YouTube sometimes", she said.
"I have much more experience right now". "I know that it's 20 years ago that she won here the last time". So this is why I was a little bit nervous when I went there because I know that I have to play good tennis against Venus. She also said she would love to return here next year.
"I'm just happy to be in my second grand slam final".
Speaking about her match against Venus, the Kerber admitted that her plan was to wear the 36-year-old down.
Vesnina lasted three minutes longer than countrywoman Dinara Safina did against Venus Williams in the previous shortest modern era women's semi-final in 2009. "I don't think I would deserve to be paid less because of my sex, or anyone else for that matter in any job".
After a running cross-court forehand victor capped the 19-stroke exchange that ended her victory, Kerber tossed aside her racket and dropped to her knees at the baseline.