United have lost just once in all competitions since late January and should be confident of getting a positive result in the quarter-final first-leg in Holland on Thursday night.
Where can I watch Atletico Madrid vs Leicester City? "Atletico are a very durable side, have a lot of experience in the Champions League, have good players but will be concerned about Leicester's strengths", he said.
"Football is marvellous. No one has the absolute truth in how to win", added Simeone. Here is all the information you need to know for the game, including team news, live stream links, possible starting lineups and more.
"We've got a lot coming up - Wednesday, Saturday and Tuesday - but we've got a good squad", he said.
This is slightly puzzling when you consider that of Atletico's eight Champions League games this season, only two have seen three goals or more. "It defends very well in the back and relies on counterattacks a lot", Luis said.
Real Madrid, meanwhile, have the crowning fixture as they prepare to take on former manager Carlo Ancelotti's Bayern Munich, and lastly, we have the game of who has the better youngsters when Borussia Dortmund take on AS Monaco.
We know Monaco have been scoring bags of goals while Dortmund have been building a bit of momentum with their young side, with Ousmane Dembele the one I've really been impressed with, and all eyes with be on Kylian Mbappe for the visitors.
Shakespeare's flawless start ended with Sunday's 4-2 defeat at Everton when he fielded a heavily-rotated team with one eye clearly on Wednesday's game, in which they will be without injured captain Wes Morgan.
Atletico struggled with inconsistency early on but Simeone was able to get the team back on track entering the final stretch.
In fact, 25% of Leicester City's games in European competition have taken place against Atletico Madrid (4 out of 16).
The in-form France striker has scored seven times in his last nine games for club and country and is the hosts' biggest threat with 25 goals so far this term.
Yet Leicester are not here as sightseers and that was the point Shakespeare really wanted to make amid questions surrounding Claudio Ranieri's claims someone at the club may have deliberately undermined him - or, as it was put to Shakespeare from the front row of assembled journalists, "stabbed him in the back". The team won six straight games under replacement coach Craig Shakespeare until a 4-2 loss at Everton on Sunday, when several regular starters were rested.
"These players deserve that opportunity and we want to show that tomorrow night".
"We have enjoyed it but we are there to compete and not to just make the numbers up".