The talented Brazilian, who joined the club in January leading many to doubt whether the two could both play in Pep Guardiola's fluid system.
Up front, Roberto Pereyra (groin) and Mauro Zarate (cruciate ligament) are the men who will not play any part on Saturday. He was so important last season.
As for the hosts, Marco Silva's Watford side are now fourth in the Premier League table with eight points from four games this season, coming off the back of just one win in three in all competitions.
Manchester City could welcome captain Vincent Kompany back from a calf problem.
"We need him. I need him and the team needs him".
His prolific strike partner Sergio Aguero is just as happy when facing Watford.
City have now won 11 and drawn four times in the 15 Premier League matches Jesus has appeared in since arriving from Palmeiras in January.
It's nearly 35 years to the day since Graham Taylor's Watford beat West Bromwich Albion 3-0 to move top of what was then the First Division.
Watford have kicked off their 2017-18 Premier League campaign with a bang, and a lot of it is down to defensive solidity that has been apparent for everyone to see under Marco Silva. The Hornets are playing with a lot of confidence at the moment.
With Watford yet to best their Premier League superiors since the division's inception in the early nineties, a win for Silva's side seems unlikely this weekend, with such a strong attacking force at City's disposal. In England there is a bit more: "Arsenal, Chelsea, Tottenham, Liverpool, Manchester United and Manchester City".
"Maybe we don't have time for that".
Guardiola insists this does not mean his players lacked belief previously, but it is important to build on what they have.
Watford fans could be forgiven for having a sense of deja-vu ahead of tomorrow's game.
Ilkay Gundogan has showered praise on Sergio Aguero following Manchester City's thumping 6-0 win at Watford on Saturday afternoon. Then they had two wins over Bournemouth (1-2) and Liverpool (5-0) after a draw (1-1) to Everton.