Then, junior punter Dominic Panazzolo's punt was blocked by Oklahoma State, putting the Cowboys on Tech's 9-yard line.
However, Ammendola also made a 22-yarder and a 27-yarder on the night.
On the ensuing Oklahoma State drive, Rudolph was able to convert a 3rd & 5 from his own 26-yard line.
Texas Tech: A win likely would have meant the Red Raiders' return to the poll for the first time since Kliff Kingsbury's first season in 2013, when they started 7-0.
Rudolph's second rushing score after halftime followed three first-half TD tosses as the Cowboys (4-1, 1-1 Big 12) bounced back from a home loss to ninth-ranked TCU and avoided a second early conference loss in their pursuit of the revived Big 12 championship game.
Texas Tech's final opportunity with the ball ended with four straight incomplete passes as Shimonek was pressured heavily by the Oklahoma State defensive line. Shimonek was just 29 of 45 for 330 yards, one touchdown and one interception. Rudolph also rushed for 50 yards and two touchdowns.
The Red Raiders (3-1, 0-1) couldn't corral running back Justice Hill (30 carries, 164 yards) or receivers James Washington (nine catches, 127 yards) and Marcell Ateman (six catches, 114). In three previous games against Tech, he had 13 catches for 445 yards and five touchdowns.
Once in the red zone, Rudolph dashed into the end zone on a quarterback keeper, a play that had been effective all night for the Oklahoma State offense. This tied the game, 7-7, with 7:42 left in the first quarter. Fields was manned up on a Cowboys wide receiver on the far sideline when he broke on Rudolph's pass towards the sideline and was able to intercept it cleanly. Tech tied the game, 34-34, with 9:56 left in the game when Nisby ran in a 1-yard touchdown.
The Cowboys next possession ended in the red zone again, this time with a missed field goal from 22 yards.
Oklahoma State wide receiver Jalen McCleskey makes a second quarter touchdown catch against Texas Tech in an NCAA college football game Saturday, Sept. 30, 2017, in Lubbock, Texas. The touchdown pass capped off an eight play, 80-yard drive with 14:14 left in the second quarter.
Even after the momentum boost, Texas Tech struggled on offense for a majority of the first half, notching just 10 points in addition to Fields' defensive touchdown.
The Red Raiders will next travel to Kansas to face the Jayhawks at 11 a.m. on Saturday, Oct. 7, in Lawrence, Kansas.