La Roja sealed their spot as Group G winners with Friday's 3-0 win over Albania, Thiago netting the third to cap a devastating opening 26 minutes in Alicante.
Spain's Isco celebrates scoring his side's second goal with teammates on Friday.
After not being afraid to air his views on the Catalonia Independence Referendum, Gerard Pique endured a rough ride as Spain qualified for the 2018 World Cup Finals, in Russian Federation. "We are delighted and proud of what we have achieved because it's very important for Spain".
The whistles and boos appeared to affect Pique, who picked up a yellow card in the second-half for pulling back an opponent - a booking which rules him out of Spain's final group game away in Israel.
Lopetegui was adamant the suspensions were not planned.
"I only focus on playing football and I am sure it´d be better if everyone else did the same", Busquets said in a radio interview.
Albania boss Christian Panucci, who saw his side hit the post during a second-half purple patch, believes Spain have the capacity to go all the way in Russian Federation next year.
In the team Spain, the player Alvaro Morata is lost due to injury, The team has no help from the political side and they are offering to quit the national team. You've seen their quality.
The defeat ended Turkey's hopes of qualifying but Iceland moved two points clear at the top of the table heading into the final round of matches - when they face bottom-placed Kosovo - after Croatia could only draw at home to Finland.
Albania actually had a golden chance to get their name on the scoresheet in first-half stoppage time when Grezda robbed Gerard Pique inside the Spain box before attempting to find Llullaku, but Ramos was across to make a fine clearance. "We created four or five opportunities, which against Spain isn't easy".