Thousands of Iranian demonstrators have taken to Taleghani Avenue, the street facing the former US embassy in Tehran, to mark their National Day of Fight Against Global Arrogance.
In 1979, 38 years ago today, the U.S. embassy in Iran was overrun by student demonstrators who supported Iran's Islamic revolution.
Demonstrators held anti-U.S. and anti-Israel signs and chanted slogans, including "Down With the USA", condemning Washington's policies toward Iran.
The United States has also imposed new sanctions over the Islamic Republic's ballistic missile programme.
Trump's administration has taken a tougher line with Iran, threatening to tear up an global accord on its nuclear programme. The U.S. cut its diplomatic relations with Iran after the embassy takeover and has had no diplomatic relations since.
Tighter security was handled by Iranian police and the hard-line Islamic Revolutionary Guard Corps.
Speaking about the students who stormed the US embassy, Iran's former chief delegate to the United Nations, Rajaie-Khorassani said, "I don't know if the intention of these boys is to prevent any movement toward the United States, but it is one of the inevitable consequences".
Iranians who gathered at the embassy echoed the defiant words of Iran's supreme leader, Ayatollah Ali Khamenei, who last week called the United States Iran's "No. 1 enemy".
In an address to the Saturday rally in Tehran, Secretary of Iran's Supreme National Security Council (SNSC) Ali Shamkhani said that the US's foreign policy had failed.
This year, amid strained relations between Tehran and Washington over the nuclear deal and belligerent rhetoric from US President Donald Trump, the traditional display of military strength has taken on added significance.
Anti-Iran measures adopted by the USA have strengthened the Iranian nation's power, Shamkhani said on Saturday.
Hasan Shorjeh, a retired teacher carrying a "Down with America" placard, said there was no point in respecting the nuclear deal if the United States doesn't hold up its end of the agreement. "The enmity with America will continue and our resistance will as well".