Flowers also set school records for career touchdown passes and rushing yards, finishing with 34 school or conference marks.
The second came on a perfectly time wheel route that got past the Red Raiders' defense.
Texas Tech finished the season 6-7, and the Bulls finished 10-3.
On offense for Texas Tech, it should be another lethal passing attack led by former Iowa transfer Nic Shimonek. Flowers once again delivered the heroics with a key 21-yard run on a 3rd and 10 and followed that up with a 26-yard touchdown pass to Tyre McCants to go up 38-34 after the extra point. Tech marched to the USF 13 on the final play of the game before T.J. Vasher was stopped short of the end zone. The Bulls went three-and-out on their next possession then Texas Tech drove 66 yards to break the tie with 34 seconds left in the quarter on a 5-yard touchdown pass from Shimonek to Keke Coutee.
Coutee, a junior wide out for the Red Raiders, finished with 11 receptions for 187 yards and a touchdown. It's a low scoring affair in the first half with a 10-10 halftime score.
Texas Tech's offensive line struggled to contain Deadrin Senat who sacked Shimonek 3 times in the first half.
Texas Tech continued to pile up the yards but the South Florida defense kept the Red Raiders out of the end zone and off the scoreboard in the second quarter.
Texas Tech's defense started the Birmingham Bowl well.
South Florida was able to stifle the Red Raiders offense for the win.
The Red Raiders high tempo offense gets going after the second play in the third quarter when Kolin Hill forces Flowers to fumble the ball and Demarcus Fields comes up with it. Texas Tech's 28th takeaway of the season. From there the quarterbacks took center stage, with Flowers leading the Bulls on two touchdown drives and Shimonek leading the Red Raiders on one.
South Florida converted a fourth-down on the first play of the quarter and drove as far as the Red Raiders' goal line but could not convert a fourth-and-goal attempt at the 1-yard line to tie the game. South Florida retook the lead, 31-27, two plays later on a 64-yard touchdown pass from Flowers to Scantling with 4:26 left to play in the contest.
Flowers scrambled for 21 yards to setup the game winning touchdown.