The National Weather Service in La Crosse forecasts heavy snowfall on Thursday and into Friday morning.
The classic "mixed bag", is forecast.
Beginning Wednesday night and continuing through Friday evening, there will be a chance of snow in the region, with the likelihood of snow at 80 percent Thursday and Thursday night, followed by a 50 percent chance on Friday and the snow tailing off Friday evening, the NWS reports.
"It's hard to get excited about our snow chances for Christmas", said Wes Junker, Capital Weather Gang winter weather expert. And, it'll be unseasonably warm again with highs in the mid 40s with morning rain.
Forecasters have warned that "lashings of rain" will batter parts of northern and western Britain on Saturday and into Christmas Eve, though most other places should remain dry.
"Frigid weather arrives for the week between Christmas and New Year's with meandering bands of Lake Effect snow squalls making for hard to risky travel at times around the Great Lakes".
COVER IMAGESGambling on a White Christmas has increased after the recent cold snap
The National Weather Service criteria for a white Christmas is at least one inch of snow on the ground at 7 a.m. December 25.
There has not been more than 0.3 inches of snow on Christmas Day in Buffalo since 2003.
In St. Louis, according to the map, there is a 21-percent chance of at least 1 inch of snow on Christmas.
Tuesday's high temperature isn't expected to escape the teens.
Overnight lows are forecast in the teens, the weather service said.
Temperatures in the single digits are expected by early to mid next week.