The Reds came from 2-0 down in the second half to win 3-2 as Nemanja Matic completed the remarkable turnaround with a stunning strike in injury time for his first goal for the club.
Palace's 18-match and 27-year wait for a top-flight win over United continues, but Roy Hodgson will be more concerned about where there next win of any description is coming from. Their assured performance in the second half stemmed from the control they had in midfield, thanks to the trio of Matic, McTominay and Pogba.
Fierce rivals and league leaders Manchester City now have a gap that's over 10 points to Jose Mourinho's men who are in second. Manchester United is just a single point adrift of the Reds with a game in hand and Tottenham follows the Old Trafford outfit closely with 58 points. Similarly, a United win coupled with under 2.5 goals in the match is 23/10.
"There are five or six teams in this division that can compete for the title". The defensive errors, not just from the back line, made United look amateur for the first part of the game.
For Crystal Palace, there are not many names to keep an eye on, but Wilfried Zaha is one that could pose a threat against Manchester United.
After inspiring his side towards the relative safety of mid-table, a succession of injuries has undermined Hodgson and left his team struggling at a time when their rivals are again gaining vital points.
Klopp and his players offer a different type of challenge and Jose Mourinho will truly prove that he still remains a top coach should he succeed in guiding his players to another win.
United then fell asleep early in the second half. Manchester United loanee Timothy Fosu-Mensah is ineligible for this game due to the fact that he can't play against his parent club.
It wasn't long before they fell behind through the cleverness of Townsend, who found the top corner with the help of a deflection from Victor Lindelof on the edge of the box. Antonio Valencia and Ashley Young could be the two fullbacks in the four-man backline.
Liverpool played Newcastle United and won 2-0.
Recent form for Manchester United has been patchy at best - a scrappy home win over Chelsea joined comfortable enough wins over Huddersfield and Burnley.
GK David De Gea, 7 - There was nothing he could have done about the deflected goal, but it was puzzling as to why he didn't even move for the second.