Fars news agency said a group of hardliners gathered at Tehran's International Mehrabad Airport to protest Le Drian's visit.
The Iranian foreign minister noted that the International Atomic Energy Agency (IAEA) has confirmed in ten reports Iran's commitment to the JCPOA, adding the Europe can play a more constructive role in preserving this international achievement.
Any collapse of the 2015 nuclear deal between Iran and major powers would be a "great loss", the head of the United Nations atomic agency policing the accord said on Monday, alluding to a USA threat to pull out of it.
"As of today, I can state that Iran is implementing its nuclear-related commitments..."
Yukiya Amano made the remarks in his introductory statement to the meeting of IAEA's Board of Governors in Vienna Austria, on Monday March 5, 2018, IAEA website reported.
Trump in January set a 120-day deadline for USA lawmakers and European allies to "fix" the agreement or face a US withdrawal.
He added that all signatories to the JCPOA must equally attach significance to preserving "this global diplomatic achievement", noting that it would not be effective to give only verbal support to the deal.
President Donald Trump has been consistently critical of the deal, warning that he will withdraw USA support if it is not renegotiated.
"If America pulls out of the deal".
Le Drian said there was "still a lot of work to do" on Iran's missile programme after meeting with top officials, including President Hassan Rouhani and Foreign Minister Mohammad Javad Zarif.
"Iran has learned from the bitter experience of the imposed war that it must rely on its deterrence power to defend the people", Zarif asserted. France increasingly has criticized Iran's ballistic missile program since the deal.
He added that France seeks continuation of friendly ties with Iran.
"Iran's missile program will continue non-stop and foreign powers have no right to intervene on this issue", the semi-official Tasnim news agency quoted Iranian Armed Forces spokesman Masoud Jazayeri as saying.
"In order to keep the United States in the Iran nuclear deal, European countries are suffering from extremism and this will ultimately undermine Europe's policy", he told Tehran-based Etemad daily.
The top security official added, "Failure to implement the JCPOA discredits worldwide agreements and also logic of holding talks to settle global issues".
Iran claims that it will continue its programs despite the pressure from the USA and other Western countries.
Le Drian said that France is determined to implement and protect the nuclear deal.
Le Drian has insisted he is not "an emissary of Trump", but he has taken a firm line on Iran's missile programme and regional interventions that mirrors the rhetoric from Washington. According to the French Treasury, Iran's trade exchanges with France stood at 3.8 billion Euros past year.