But the clash is sandwiched between two games of even greater magnitude in the context of their season - a trip to Anfield on Wednesday and the second leg next week.
"Manchester City's problems at the back left them short last season but goalkeeper Ederson has made a huge difference, giving them a renewed confidence and the best defence in the league".
But this would not be pragmatic. He has not trained but the City manager suggested his team will attack Liverpool, with or without Aguero. They are an extraordinary team'.
'Because everyone moans about the fact that English teams aren't as good in the Champions League as they used to be, and the Premier League is not as good.
The likes of Kevin De Bruyne and Sergio Aguero were on show, along with Raheem Sterling, Bernardo Silva and Gabriel Jesus. We know that. They are so quick, they are so tough but it's the quarter-finals of the Champions League so we can not expect something at this level is going to be easy. It's special. It's important we win (the title) - no matter where. With 37 goals from 41 appearances in all competitions, Mohamed Salah's form in front of goal has earned comparisons (albeit overblown) with Barcelona star Lionel Messi, while Sadio Mane and Roberto Firmino have also proved their capabilities in the Champions League this season.
Guardiola may have taken City to the brink of being crowned Premier League champions but he is braced for a tough test against the Merseysiders in their Champions League quarter-final.
And it's no wonder they looked content. following their Toffees victory, Guardiola and Co now know that three points at home to United would secure not only local bragging rights, but the title. If we are not able to win, we have six more chances. When the players are in position they move every millisecond in order to be available.
"We will be excited about the opportunity to play City in a quarter-final early enough, but in the moment we are still enjoying this result".
The Premier League's highest-paid player had gone seven games without a goal until he finished off Jesse Lingard's pass.
What time does the Liverpool vs Manchester City match start?