It is the toughest remaining game of the season on paper for City and they will be desperate to turn their form around after a derby day defeat to Manchester United and Champions League elimination at the hands of Liverpool.
"After 14 games unbeaten there is no point talking about the player that has not played and has been injured for a long time".
"We have the quality, the right spirit and the experience in the Premier League", said captain and goalkeeper Hugo Lloris.
The Premier League's Goal Accreditation Appeals Panel credited the England striker with the second of Spurs' two strikes in the weekend win at Stoke City, moving him four shy of Golden Boot leader Mohamed Salah.
It was put to Pochettino that, in claiming a team-mate's goal, Kane had seemingly put personal ambition above collective success.
Kane's Tottenham face Manchester City at Wembley on Saturday.
"It's not about one result, that we're going to show that we're ready or not ready", he said.
As Spurs fans, if we're honest with ourselves this is just a tad cringe-worthy, but that mostly comes down to Kane's public comments ahead of the appeal.
In that time Spurs have all-but booked their Champions League spot for a third successive season and they could pour more misery on a faltering City side.
"I care about the goal because it provided us the three points but all that happens after is more players' decisions or the club's decision", he added.
"Of course the fans feel disappointed that he chose to move to City", the Tottenham manager said. "I don't know if they're the best but if you make your top five, I'm sure all the managers and football people are going to name them both".
"I think we need to keep pushing, winning games and a massive three points against Manchester City", he said.
While City will be keen to get the title wrapped up as soon as possible, Spurs have their eye on a strong finish to the campaign as they target second place.