ABC News reported that Camille called her husband's conviction a product of "mob justice", and called it a "tragedy" that her husband of 54 years could spend the rest of his life in jail as a result of the convictions.
A spokeswoman for the Montgomery County District Attorney's Office said prosecutors do not have a response to Camille Cosby's statement.
"In the case of Bill Cosby, unproven accusations evolved into lynch mobs, " she wrote. McMonagle later parted ways with Bill Cosby before his second trial.
Camille Cosby, 74, who attended her husband's three-week trial in Norristown, Pennsylvania only during closing arguments, claimed that Constand had concocted the sexual assault claim in the hope of winning a civil judgment against the actor.
"The overall media, with their frenzied, relentless demonization of him and unquestioning acceptance of accusers' allegations without any attendant proof, have superseded the Fifth and Fourteenth Amendments, which guarantee due process and equal protection, and thereby eliminated the possibility of a fair trial and unbiased jury", she vented.
The statement went on: "Since when are all accusers truthful?"
She compared his treatment to Mr Till, the black teenager who was kidnapped and murdered after witnesses said he whistled at a white woman in a MS grocery store in 1955, and Darryl Hunt, a black man wrongly convicted of raping and killing a white woman in North Carolina in 1984. She argued that her husband's conviction was the result of "exploitive and corrupt" politics after Montgomery County District Attorney Kevin Steele advocated for the comedian's conviction, and she said that Steele and his team's "primary objective is to advance themselves professionally and economically at the expense of Mr. Cosby's life".
Mrs Cosby said Mr Steele and his team were "exploitive and corrupt" and their "primary objective is to advance themselves professionally and economically at the expense of Mr Cosby's life".
Cosby faces up to 30 years in prison.
Constand was one of more than 50 women who have accused Cosby of sexually assaulting them.
"I am publicly asking for a criminal investigation of that district attorney and his cohorts", she wrote.
It continued: "We, the majority of the people, must make America what it has declared itself to be.a democracy.not to be destroyed by vicious, lying, self-absorbed paradigms of evilness".
Her statement did not address behavior Cosby has admitted to, such as philandering and contention that he was having a consensual affair with Constand.