"He only responded to two women, two women of color", Hayek said.
"This is a new era for men", Hayek said.
For her part, Hayek celebrated the fact that it is becoming hard to hire known female writers and directors because so many of them are getting snapped up by studios.
Unless they made sacrifices, she said, "it is going to be hard for equality".
In a discussion with the Radio Times, Cumberbatch called on male actors to step up to the plate and refuse to take more money than what their female counterparts were being paid, even going as far as to reject work outright. "Otherwise they will kill the movie".
Halfway up the stairs at the Palais des Festivals at the Cannes Film Festival on Saturday stood 82 women, representing the 82 female directors who have climbed those same stairs since the first year the festival was held, 1946.
"You had a good run, but it is time now to be generous with the actresses", she said.
Hayek accused the disgraced Weinstein of sexual harassment back in 2002, when she was filming the movie "Frida". "So he went attacking the two women of colour, in hopes that if he could discredit us, he could then maybe discredit the rest".
On Sunday, 82 women, including Cate Blanchett, Jane Fonda and directors Agnes Varda and Ava DuVernay protested the lack of female directors included in the festival's line up, by standing in silence on the red carpet.
While Weinstein and his team issued generic denials of many women's accusations, Hayek's and Nyong'o's allegations were among the small handful they addressed by name. The actress-producer said she had sold four TV shows about women this year.
Hayek said it was hard to hire known female writers and directors in the United States now, as studios are snapping them up trying to catch up with the public mood.
Hayek went on, "It's a proven fact that women of colour are less listened to".
In the wake of the scandals that have followed Weinstein's downfall, Hayek said men in Hollywood "are terrified" and that "predators are hiding". "Men have the opportunity, which is so handsome, to rethink what does it mean to be a man".