Reports from Spain suggest Aguero's former club Atletico Madrid are keen to re-sign him before next season. "It's something nobody ever did before - and we want to do it", the Portuguese global told reporters.
"I think it's not going to happen".
"I said not too much [will change] but it depends on the players", he said.
"Last season, I said maybe 1,000 times that Sergio will stay until he decides his time is over".
He left Atletico to move to City in 2011 and has gone on to become the club's record scorer with 199 goals.
"I'm settled here, the players, the staff, the fans, they all help me and I feel better and better every day".
He has publicly stated he intends to return to Argentina and play for boyhood club Independiente once his time with City is up.
Getting the three points on Sunday to finish with exactly 100 clearly means a good deal to the Spaniard, who noted after City's 3-1 steamrollering of Brighton & Hove Albion on Wednesday that it would "finish this nearly ideal season".
"But we are going on holiday in a few days".
"We all want him to stay as long as possible", he told reporters, according to BBC Sport.
Sterling, who joined City from Liverpool for £44m in the summer of 2015, earns about £170,000 a week on a deal that has two years remaining.
Guardiola also expects Sergio Agüero to stay, though he could not be unequivocal.
The 2017/18 Premier League season is almost over, but how much do you remember about the last 10 months of rollercoaster action?
"We made a high investment last year because it was an old team - 10, 11 players more than 31 years old".
"Now we will make some changes with Yaya leaving. One, maybe two, but not too many".
Guardiola added: "It looks ridiculous in all respects".