The Portugal No.7 saw his penalty saved by Iran goalkeeper Ali Beiranvand, who leapt left to deny Ronaldo his fifth goal of Russian Federation 2018.
Portugal's dramatic 1-1 draw with Iran in Group B's final round on Monday included the 19th and 20th spot-kicks of the tournament.
The role of VAR goes a long way to explaining this trend, with seven penalties so far being awarded following a video review and VAR has also confirmed referees' decisions on the field on several occasions.
At 34 years and 272 days, Ricardo Quaresma became Portugal's oldest World Cup goal scorer following his stunner against Iran.
Of the 98 goals scored at this World Cup, 24 of them have come after the 75th minute.
Iran were awarded a penalty for a handball by Cedric Soares which understandably angered the Portugal players.
Now Cristiano Ronaldo and his team must face Uruguay in the last 16. "You have one system which costs a fortune.and nobody takes responsibility".
Uruguay are to face European champions Portugal Sochi at 1am on Sunday (Thailand time) while Russian Federation now are set to play Fernando Hierro's Spain, the 2010 world champions, at 9pm on Sunday in Moscow. "And then we got a red card". This meant all of Spain's first five goals at the 2018 World Cup have been scored by Madrid-based players - Diego Costa of Atletico Madrid (three) and Nacho and Isco of Real Madrid (one apiece). Meanwhile Spain had a late equaliser disallowed for offside, being VAR decided it should be given as Iago Aspas was onside.
Two such decisions were in the Portugal-Iran match. There was minimal contact and Caceres originally waved off a foul. How many officials are going to be bold enough to make that call when they have time to think about it? Once replay is introduced, there will be fiddles and fixes, parameters changed and new guidelines introduced, all in the hopes of eliminating the mistakes people make with a system run by people.
Carlos Queiroz, Iran's coach, said after the game that VAR should be scrapped, and it was a sentiment echoed by many.