Mayfield's first completion of his career went to Jarvis Landry for a 14-yard gain on first-and-10.
Down 14-0 the Browns brought in the former Heisman Trophy victor to try and salvage some pride for a team that was in the midst of the NFL's second longest winless streak since the AFL-NFL merger in 1970.
At the start of the play, Mayfield ran out of the backfield on a pass pattern and the ball was directly snapped to running back Duke Johnson Jr. He led the Browns on three more scoring drives, including the eventual game-winning touchdown by Carlos Hyde with just over two minutes to go. The rookie quarterback drove his team 39 yards down the field, which set up a 45-yard field goal by new Browns kicker Greg Joseph.
He also caught a two-point conversion on the same play he scored on to end the first half against Georgia in last year's Rose Bowl. On Thursday night against the Jets, Taylor struggled mightily and the Browns fell behind 14-0. "I can't tell you if he would have performed like that week 1", Jackson said.