"President Tran Dai Quang died today despite the utmost efforts from doctors", the post said.
Vietnam's President Tran Dai Quang died at a military hospital in Hanoi on Friday at 61, reported Vietnam News.
Mr Quang was one of Vietnam's top three leaders - Vietnam has no paramount ruler and is also led by the prime minister and Communist Party chief.
According to a statement from the commission, President Quang was in critical condition and has received treatments from a medical team at home and overseas.
Born in 1956, Quang's career began in Vietnam's Ministry of Public Security, an agency heavily inspired by the Soviet Union's KGB, where he rose through the ranks in the 1970s and 1980s.
Vietnam President Tran Dai Quang has died on Friday, state television and radio announced.
The head of state also lauded Tran Dai Quang's personal contribution to cultivating the comprehensive strategic partnership between Russian Federation and Vietnam and bilateral cooperation in various spheres.
Quang hosted President Trump when he made his first state visit to the country during the Asia-Pacific Economic Cooperation (APEC) CEO Summit in Danang a year ago.
According to The Associated Press, "The state-run online newspaper VnExpress quoted a former health minister and the head of a national committee in charge of leaders' health, Nguyen Quoc Trieu, as saying that Quang had contracted a rare and toxic virus since July past year and had traveled to Japan six times for treatment". The death of the president does not destabilize the dictatorship: the real number one of the regime remains the general secretary of the Communist Party, Nguyen Phu Trong. Last week, during a ceremony with the president of indonesia used for joko Widodo, it appeared particularly weak.
His time in office was dominated by a simmering conflict with Beijing over the South China Sea, a long-running dispute between the communist neighbours that escalated on several occasions.