Speaking in Cairo on the tour's final leg, Trump praised her husband's Supreme Court choice, Brett Kavanaugh, and said she was glad he and his accuser had a chance to be heard following allegations of sexual assault prior to Saturday's Senate approval of his nomination.
In Egypt, the former model posed in front of the Great Sphinx of Giza wearing a tailored trouser suit which many social media users said made her look like a certain fictional Nazi.
However, following reports of her husband, President Donald Trump describing some African countries as a "shithole" in February, Mrs Trump's visit could also be an attempt to build diplomatic relations.
"That's very important what I do, what we're doing with USA aid and what I do with my initiatives and I wish people would focus on what I do, not what I wear", she said. "I give him my honest opinion and honest advice and sometimes he listens, and sometimes he doesn't".
First lady Melania Trump is visiting Africa on her first big solo worldwide trip.
Her trip through four African nations-Ghana, Malawi, Egypt, and Kenya-has featured her doing numerous things you would expect of someone going on a stereotypical vacation through the Motherland, including going on a safari and visiting the Sphinx.
"She started that on Day 1, when she announced she wasn't going to be moving to the White House right away", said Anita McBride, who was Laura Bush's chief of staff. "People are not used to seeing the light of day between a president and first lady, but by occasionally doing that, she demonstrates she is her own person".
Back home, Washington was in turmoil, but the first lady had something on her mind.
Who could forget the time she wore a pair of Manolo Blahnik stiletto heels to tour a Puerto Rican disaster zone?
But wildlife conservation has not been Melania Trump's only focus during her four-country tour.
It didn't take long for the typically reserved USA first lady to dive fully into the moment.
Image copyright AFP Image caption Like many first ladies, Melania Trump has chosen to use her platform to discuss issues affecting children.
Each stop was meant to call attention to the work of USAID, her partner on the trip.
In the past, her clothing choice has sparked widespread comment, notably when she wore a coat emblazoned with the slogan "I really don't care, do u?" while boarding a plane to visit migrant children at the Texas-Mexico border in June.
Mrs Trump was welcomed by Egyptian President Abdel Fattah al-Sisi and his wife, Entissar, on Saturday after she flew in from Kenya as part of her first solo African trip.
A big talking point on the trip was the outfits she chose to wear, opting for Daring colonial-inspired attire. "It is a handsome thing to see".