Christie's, a global auctioneer headquartered in London, is selling several of Hawking's papers, including his dissertation, thesis on the origins of the universe and his spectrum of wormholes.
Estimated prices range from £100 ($130) for a limited-edition print of Stephen Hawking's Time Travellers Invitation to £150,000 ($195,360) for a photocopy typescript of his PhD thesis (signed and inscribed) from 1965.
"You can see each advance as he produced it and introduced it to the scientific community", Mr Venning said.Stephen Hawking DiesHawking passed away on March 14 in his home in Cambridge, England.
Hawking was diagnosed at age 22, just after starting his doctoral studies, and doctors initially said he would only live a few more years.
Hawking, however, returned to school, Venning said, and his thesis "was the fruit of his reapplying himself to his scientific work".
The disease eventually left Professor Hawking nearly completely paralysed.
The motorized wheelchair that carried Hawking out of the 1980s and into his most high-profile period also is on the auction block, with Christie's reportedly expecting it to fetch between $13,000 and $20,000. He communicated through a voice-generating computer and moved in a series of high-tech wheelchairs.
Having run over Prince Charles's toes during a meeting in 1977, he is said to have regretted not doing the same to the then-Prime Minister Margaret Thatcher.
The sale includes a script from one of Professor Hawking's Simpsons appearances, a copy of his best-seller A Brief History of Time signed with a thumbprint and a personalized bomber jacket that he wore in a documentary.
Daughter Lucy Hawking said that "through the auction, fans of the scientist will get the chance to become owners of relics, reminiscent of the extraordinary life of a theoretical physicist".
His children hope to preserve his scientific archive for the nation.
Documents and files by Stephen Hawking the personal and academic possessions of Stephen Hawking at the auction house Christies in London, Friday, Oct. 19, 2018.
The 22 lots will be a part of the online sale On the Shoulders of Giants, which will feature rare and important autograph letters and manuscripts by Isaac Newton, Charles Darwin and Albert Einstein, and other leading scientific forebears.