Former 49ers quarterback Colin Kaepernick was the first National Football League player to kneel during the anthem as a form of protest against racial inequality and police brutality.
But it was ultimately up to Mullens to take advantage of each situation. A cool 16-of-22 for 262 yards, three touchdowns against zero interceptions and a passer rating of 151.9.
The Raiders, who lost their fourth straight and remained winless on the road (0-4), drove 56 yards in 10 plays on their first possession of the game, but a sack and a holding penalty after the visitors had reached the San Francisco 13 forced a 37-yard field goal by Daniel Carlson for a 3-0 lead.
Raheem Mostert added a 52-yard touchdown run and the Niners outgained the Raiders 405 to 248 for the game.
If this wasn't the low point of Oakland's season, then these last eight games (including two against the Chiefs) are going to be brutal for Raiders fans.
Nick Mullens got several hundred congratulatory text messages, a phone call from Brett Favre and his Twitter account verified.
The 49ers, who struggled against the Cardinals, looked like a playoff team against the Raiders.
Kyle Shanahan said he wasn't told whether Mostert was done for the year, but added, "I would assume so with a broken arm". Dekoda Watson had 1 1/2 sacks in his first game of the season after getting activated from IR earlier in the day. Owens was voted into the Hall of Fame earlier this year but skipped the induction ceremony in Canton, Ohio, to hold his own celebration at his college in Chattanooga, Tennessee.
Raiders left tackle Kolton Miller left with a knee injury.