A classic Premier League rivalry will be renewed in the final match of Gameweek 15, as Manchester United play hosts to Arsenal at Old Trafford on Wednesday.
Alexandre Lacazette capitalised on a Marcos Rojo mistake in the second half only for Jesse Lingard to respond nearly immediately, meaning each side had to settle for a draw that does not greatly benefit their top-four ambitions.
Mourinho suggested after the game that it would be a miraculous achievement if Manchester United finish in the top four, but the Portuguese has done a volte-face on those comments.
Unai Emery is credited with revolutionizing Arsenal in his first months as head coach, but will he change the Gunners' wretched luck at Old Trafford?
The Gunners nearly won it during the closing stages when Lucas Torreira was denied by De Gea, but a draw was a fair result as Arsenal extended their long unbeaten run and United were made to wait for another win in the top flight.
While they may be two of the most successful sides in Premier League history, it has been a troubled few years for Arsenal and Manchester United.
Things were said to have improved in recent times, but this week came the explosive claim that Mourinho branded Pogba a "virus" in front of teammates post the disappointing 2-2 draw with the Saints.
When Manchester United swapped Henrikh Mkhitaryan for Arsenal's Alexis Sanchez in January, we thought it was a steal. "He'll have a major decision to make and there'll be five or six teams interested".
Mourinho has made Chris Smalling and Victor Lindelof his first-choice pairing this season but Koulibaly is a better defender when compared to the two.
That dramatic pattern would be repeated after 68 minutes when Arsenal regained a lead they could only hold, on this occasion, for 74 seconds.
The manager attempted to put a positive spin on the result, despite leaving his team languishing in eighth position - below Bournemouth - by reminding the world that, "the last four matches, we didn't lose".