According to Channel Nine, the consulates of Britain, the United States, India, Indonesia, South Korea, Germany, Italy, Switzerland, Pakistan and Greece were all believed to have been affected.
Emergency Victoria issued eight "Hazardous Material" alerts listed within 30 minutes, with workers reportedly evacuated across the city shortly after substances were discovered.
A fire fighter is seen carrying a hazardous material bag into the Korean consulate in Melbourne.
"There are 22 we know of at least in Melbourne and Canberra", Candice said.
Emergency services in Australia are responding to multiple reports of suspicious packages delivered to a number of embassies and consulates in Canberra and Melbourne.
"Police and emergency services have responded to suspicious packages delivered to embassies in Melbourne today", an AFP spokesperson told 10 daily. "The circumstances surrounding the incidents are being investigated".
A spokesman for the USA consulate in Melbourne told CNN that after receiving a suspicious package staff "followed standard procedures and alerted local authorities".
Hazmat and fire crews are seen outside the Indian and French Consulates on St Kilda Road in Melbourne.
The Indian consulate and USA embassy, both located on St Kilda Road in Melbourne, are believed to be have been affected, as well as the Swiss, British, German, Spanish, Korean and New Zealand consulates and embassies.
A spokeswoman for the service said: "We are assisting the Australian Federal Police right now with a number of incidents across Melbourne".
The Ministry of Foreign Affairs and Trade has confirmed that the New Zealand Consulate General in Melbourne received a suspicious package this afternoon.
The developing situation comes just two days after a "suspicious" white powder was found at the Argentinian Consulate in Sydney.