"The leaders of Facebook (Fidji Simo), Instagram (Adam Mosseri), Messenger (Stan Chudnovsky), and WhatsApp (Will Cathcart) will report directly to me, and our Chief Marketing Officer (Antonio Lucio) will report directly to Sheryl (Sandberg)", Zuckerberg announced.
"I will really miss Chris, but mostly I am deeply grateful for everything he has done to build this place and serve our community", Mr Zuckerberg said.
During the a year ago, Facebook has seen a steady stream of executives depart following the Cambridge Analytica data scandal, including its chief security officer Alex Stamos, head of communications and public policy Elliot Schrage, WhatsApp founder and CEO Jan Koum and more recently, Instagram founders Kevin Systrom and Mike Krieger.
In a separate Facebook post, Cox said Facebook is turning a new page in its product direction, focused on an encrypted, interoperable, messaging network. That path will determine whether Facebook can fix its tarnished image or continue to suffer a steady drip of unflattering headlines and rack up more executive departures.
Cox has a 13-year history with Facebook, starting as one of the company's first 15 engineers, who then worked his way up the ranks. Facebook's chief security officer Alex Stamos departed and has warned the company against unbridled data collection. WhatsApp co-founder Jan Koum left over disagreements with the Facebook leadership over WhatsApp's privacy and encryption.
No replacement has been announced for Mr Cox. "Most recently, he has done a great job running the Facebook app", Zuckerberg informed.
Facebook's family of apps strategy has so far been led jointly by Cox and Javier Olivan, vice president of growth. Zuckerberg is also promising to make photos and posts automatically disappear from public view.
It also comes after an unprecedented global outage this week for Facebook and its other applications affecting millions of users, believed to be the worst ever for the network.
Zuckerberg said he does not plan on hiring anyone to fill Chris Cox's chief product officer role. "Facebook Inc.is a massive and evolving company, so it's only natural that in a company that large, not everyone will agree with every strategic change", she said.