For the Reds, the Anfield crowd will still be buzzing from Tuesday night's madness - described by many as "the greatest comeback of all time" - and while there will be some wary limbs and minds, the Liverpool fans will be urging the chosen XI for one final push for the title.
An 82nd-minute free-kick from the Argentine delivered a final blow to Liverpool, who now must score at least three times against the favourites to win the competition just to draw level in the semi-final.
Let's just keep our fingers crossed for a 14 successive Premier League win and keep everything simple...
Thanks to Vincent Kompany's howitzer against Leicester, our destiny remains in our own hands - and who would want it any other way?
It was also good enough to send social media into meltdown. Salah won it previous year with 32 goals. We know that they attack spaces very well. I will work for my team, for Arsenal and know here it will be very hard and I know here they have a big history.
Brighton's record against the top six teams is defensively quite solid.
Liverpool beat Barcelona 4-0 at Anfield on Tuesday after losing 3-0 at the Nou Camp but Marcelino believes there is plenty for his side to play for themselves.
But Arsenal seemingly blew it at Emirates Stadium the following day, with Glenn Murray's penalty enabling Brighton to claim a point after Pierre-Emerick Aubameyang opened the scoring by converting a spot-kick.
Ricardo Pereira scored the winning goal for the Foxes when the sides last met in December and was first to threaten again with a purposeful break into the box before his shot was blocked by Kompany.
Kompany's decisive contribution ranked alongside his vital victor against rivals Manchester United during the 2012 title run-in for importance and elevated him yet further among the City greats.
As so often this season, patience may well be the key.