On the night of Monday, Syrian missile defence forces reflected the missile attack at Damascus and Homs.
Israeli authorities did not remark on the incident yet.
The attack was first felt when a big explosion was heard in Damascus followed by consecutive smaller explosions, according to Xinhua reporter.
According to reports, the Israeli attack targeted the town of Tell al-Hara, located in the Daraa region, an area considered a strategic point overlooking the Golan Heights. Targets included the Jamraya research facility-considered one of the most important research facilities in the country-and Hezbollah and Iranian bases.
The Syrian news agency said the missiles struck near Damascus and in Homs province.
Rami Abdel Rahman, the observatory chief, said the strikes injured some of these forces.
In Cyprus, the foreign minister said a Russian-made missile launched from Syria landed in its territory.
The Syrian Observatory for Human rights, a United Kingdom based watchdog group, said Israel was targeting Iranian linked bases, including a base where Iran's Islamic Revolutionary Guard Corps forces are headquartered.
In the last several years, Israel has launched hundreds of strikes on Syria which it says have targeted its arch regional foe Iran and affiliated Lebanese group Hezbollah as the Israelis accuse the two of opening up a new front against Israel.
Meanwhile, Israel has conducted hundreds of airstrikes in Syria throughout the eight-year conflict, a lot of them were against what it says the targets of Iranian-backed militia groups, such as the Lebanese Hezbollah.