Pochettino has endured resounding defeats to City in the past few years, too, and there are few teams who can resist when they click fully into rhythm.
City had nearly the same team as last season against the Hammers except for the addition of Rodri to the side, and the Premier League champions seem to have picked up from where they left off last season.
Jose Mourinho last week aired that observation, along with the quip that only Manchester City's reserves could be rated as a fourth title challenger.
Spurs managed to beat Manchester City over two legs in the Champions League quarter-finals last season en route to reaching their first-ever European Cup final. To be honest I'm not thinking of that, I am thinking for us to deliver a great show tomorrow. Of course, it's an exciting game against one of the best teams in Europe.
"I was interested to see him in pre-season games and more interested to see that he wasn't involved in the first game of season". Maybe that is the key to beating a team like Manchester City'.
'We have full respect for all of the teams, from Manchester City to the other 18 opponents, ' he said.
Pochettino has played down the rivalry, insisting it is the players who matter, and joked a boxing match should decide who would come out on top. I think goals are a outcome of the way we play - their mood, how the team's playing, no injuries. It is not me and Pep. "For me the best thing to see who is the best is to go there, courageous managers, put like Anthony Joshua and create a ring to fight". We are fearless, we try to go forward, we always try to think about ourselves before the opponent. That is the point: I love to compare my team with another team.
While City plot their route through a fixture list that sees them face Tottenham, Bournemouth, Brighton, Norwich, Watford, Everton, Wolves, Crystal Palace, Aston Villa and Southampton before they travel to Anfield, last season's runners-up Liverpool - the team regarded by most as the only likely challengers to City this term - face home games against Arsenal and Spurs, plus away trips to Chelsea and Manchester United.
So, who would win in the ring?
When asked if Eriksen would remain at Spurs, he said: "I don't know". "You can be surprised". He is strong. You don't know.