Members of the British Airline Pilots' Association (Balpa) have said they will walk out for 48 hours in a long-running dispute over pay, with a further strike set for 27 September if the row remains unresolved.
The airline says once the 11.5% pay deal has fully taken effect in three years' time, some BA captains could be taking home more than £200,000 a year, allowances included.
British Airways said it was "ready and willing" to resume talks.
The UK's flagship carrier said in a statement it had "no way of predicting how many [pilots] would come to work or which aircraft they are qualified to fly".
British Airways scrapped nearly all of its timetable for the next two days as pilots went on strike for the first time in decades in a labour dispute that could cost the carrier 80 million pounds (US$98 million).
"I am really sorry that the cynical actions of the pilots' union have put us in his position", BA Chief Executive Alex Cruz told BBC television. Jet Airways temporarily ceased operations on April 17 thereby creating a demand-supply mismatch which will get worse by BA's pilot strike. In a press release they said that the strike was called "as a last resort and with enormous frustration at the way the business is now being run". Industrial action is also planned for September 27, a statement on BA's website said.
Members of the pilots union voted 93% in favor of a strike in July said CNN.
"We want to resolve this dispute as quickly as possible for our customers and, frankly, for everyone that works at British Airways", he said.
The cost of the strike is around £40 million ($49 million) per day, according to BALPA. During the strikes, BA must offer passengers reimbursement for canceled flights, alternate travel arrangements under comparable conditions or a new flight at a later date.
British Airways planes sit parked at Heathrow Airport in London on Monday.
Direct flights between London and Vancouver have been cancelled today following following a massive British Airways strike.
BA and its 4,300 pilots have been locked in a dispute that could disrupt the travel plans of almost 300,000 people in total over the two days.
The union turned down a proposed 11.5 percent pay rise for the forthcoming three years with the reasoning being they feel their workers are being shortchanged when pilots took a pay and productivity cut 10 years ago during the airline's loss-making years.
The strike is the latest setback for BA, which in August suffered its third major computer failure in little more than two years, disrupting flights in its peak travel period.